The hotel, built in the Viennese Art Nouveau style, was opened on 21 April in 1909. The design was the work of František Buldra - a Prague builder and the owner of the hotel, together with architect George Justich. Things were to change in 1924, when the new owner, Emanuel Oppel, made a point of turning the facility into a competitive 5-star hotel. Soon after, the Palace Hotel became a center of Prague’s social and cultural life. Josephine Baker was one of the hotel´s first prominent guests. Even the great opera voice Emma Destinová and her professional partner Enrico Caruso dwelled here on several occasions. Two of the function rooms were named after them. Hotel Palace Praha´s first era of long duration came to an end when it was closed on 1 January 1986. After a months-long battle, the idea of a "sensitive" renovation won out and, the Palace Hotel was saved. Its original character has been preserved thanks to the "house-in-a-house" renovation approach, i.e. leaving the outer walling untouched. The hotel reopened in 1989, and has been providing top-class service ever since, making many a world’s celebrity feel at home once again. The last renovation of the Hotel Palace Praha was during the years 2006 and 2007.

The Hotel Palace Praha is located in the city center on the corner of Panska and street and is within walking distance of the historical sightseeing attractions as The Wenceslas square, The Old Town square, Charles Bridge and The State Opera. The hotel is also close to the business, shopping and entertainment areas of Prague. Access to public transport are always close to vicinity. International airport PRG Ruzyne is 40 minutes drive and the Hotel Palace Praha can be easily reached from the central highway.

The 5-star Hotel Palace Praha is renowned for its high-quality service and luxurious guestrooms. Each of the 114 deluxe and executive rooms as well as the 10 delightful suites - such as the Palace Suite with private sauna, the Opera Junior Suite with a view of the State Opera and the Old Town Suite with a view of Prague castle - are elegantly and individually furnished. The modern bathrooms are decorated with white Carrara and Roso Verona marble and are equipped with a third telephone, cosmetic set, hairdryer and bathrobe. The hotel offers a selection of non-smoking and smoking rooms with king-size bed or two separate beds. Baby cots and extra beds for children under 12 years of age sharing a room with their parents are available free of charge. Connecting rooms for large families as well as barrier-free rooms are also available. All rooms are fully air-conditioned with individual climate control and are equipped with direct phone line with voice mail, TV with 40 channels including HBO and PAY TV, high-speed Internet access, work desk, safe, mini-bar and complimentary coffee & tea facilities.